Bishop Ann Brookshire Sherer-Simpson is a Retired Bishop of The United Methodist Church, having served from 1992-2012.
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She was born in North Wilkesboro, North Carolina, the daughter of Homer W. and Annie Jo Haigwood Brookshire. She holds an associate degree from Mars Hill Junior College (NC), a bachelor's degree from the University of North Carolina at Greensboro and a master's degree from Andover Newton Theological School (MA), and a Doctor of Ministry degree from Candler School of Theology at Emory University in Atlanta. She received the Emory Medal in 1999 and a Doctor of Divinity degree from Central Methodist University in Fayette, Missouri, in 2000.

Ann was ordained deacon and elder in the Texas Conference. While in the Texas Conference, she served pastorates in White Oak, Texarkana, and at Westbury United Methodist Church in Houston. She also served as superintendent of the Nacogdoches District of the Texas Conference.

She was elected to the episcopacy and consecrated at the 1992 South Central Jurisdictional Conference held in Forth Worth, Texas, and assigned to the Missouri Area where she served as Resident Bishop from 1992 to 2004. She was assigned to the Nebraska Area by the 2004 South Central Jurisdictional Conference, where she served until 2012.

She was a delegate to General and Jurisdictional Conferences in 1984, 1988, and 1992. She was the chairperson for the Council of Bishops Initiative on Children and Poverty from 2000 until 2004. She served on The UMC General Board of Discipleship from 1997-2004 and served on the Book of Worship Committee from 1988 to 1992. From 1992 to 1996 she was president of the Commission on the Status and Role of Women. Shewas president of the UMC's General Commission on Christian Unity and Interreligious Concerns. Sheserved asvice chair of the Board of Trustees of Saint Paul School of Theology, a curator of Central Methodist University, and a member of the boards of trustees of the Lydia Patterson Institute, Southern Methodist University and Nebraska Wesleyan University. She has visited churches and shared in mission in Zimbabwe, Mozambique, South Africa, Korea, Brazil, Cuba, Guatemala, Mexico, Finland, Nicaragua, Estonia, Pakistan, Afghanistan and the Middle East.

Her children are Robbie, his wife Jennifer and their son Max; and Ann Marie Trammell, grandson Michael Brookshire Trammell.

In 2009, Ann married Wayne Simpson.